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Phase 2 Study of Dasatinib with and without Venetoclax in Patients with Early Chronic Phase Chronic Myeloid Leukemia (ECP-CML) - Oral Presentation

Furthermore, after tests on AML12 cells (normal mouse hepatocytes), it was found that compounds 8 and 9 did not show significant cytotoxicity, while compound 7 showed little cytotoxicity

Therefore, the upregulation of these genes by p53 possibly serves to sensitise cells to apoptosis by cytotoxic T cells and natural killer (NK) cells, which can express the ligands for death receptors

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Without the copper complex, the peptide does not exert the same regenerative and collagen-stimulating effects