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It remains unclear whether direct GSH peroxidation or oxidation by DHA is the major route for H 2 O 2 -dependent glutathione oxidation (Figure 6)

Neuropharmacology 40 , 618623

In both patients with clinical UC and experimental colitis triggered by DSS in miceferroptosis-related genes were significantly up-and down-regulated, and cellular MDA content FTH and FTL protein levels were increased in IECs, and mitochondrial atrophy and mitochondrial cristae were reduced in colonic IECs of DSS-treated mice (11)

Dong KK, Damaghi N, Kibitel J, et al

& Alter, G