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Description
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In the context of these co-crystal structures, Compound 24 consistently engaged key conserved hydrophobic residues (M336, L388, F392, and F424) and formed hydrogen bonds with Q421, while additional interactions with H223, Y222, I371, H373, I428, P408, L409, M389, and V417 contributed to specificity (Figures 9AE)
[DOI] [PMC free article] [PubMed] [Google Scholar] 130.Noh H, Paik HY, Kim J, Chung J
doi: 10.1517/17460441.2010.488263

Planta Med 74:509514

PfCOCP has three putative binding sites that interact with substrates
