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CD38 is also involved in gliomas where it supports the activation of tumor microglia and macrophages and subsequent tumor progression [55]
Small molecule derivatives of 4-amino-quinoline, in particular, are non-covalent and demonstrate an IC50 values in the nanomolar range (103, 104) and include three lead compounds: 78c (IC50 7.3 nM), 1ai (IC50 46 nM), and Iah (IC50 115 nM)
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