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Poly ethylenimine (PEI) and poly amidoamine (PAMAM), both positively charged polymers, enhance BBB permeability but are toxic to cells like red blood cells and neurons in the nervous system

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From the 14th day onward, it was observed that the zebrafish generally preferred to remain near the bottom of the tank while in motion [Fig

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From a mechanistic perspective, these outcomes are mediated by multi-system endocrine adaptations, including suppression of the HPG axis, alterations in insulin and glucose-regulating hormones, reduced triiodothyronine (T3), elevated cortisol, and disruptions in growth hormone (GH) and insulin-like growth factor 1 (IGF-1) signaling [92]

As current cardiovascular risk scores do not perform well in people with diabetes [32], future studies should test and validate the implementation of kidney function measures for refined cardiovascular risk assessment