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While most organoid research has focused on hepatocyte functionality and maturation, these findings illustrate the versatility of iHLOs across a range of applications, depending on the selected timepoint

In the Krebs cycle, adenosylcobalamin can induce the accumulation of succinate, an antagonist of histone and DNA demethylation reactions catalyzed by enzymes of the 2-oxoglutarate-dependent dioxygenase family, which may favor the activation or inhibition of gene expression ( Figure 5 )