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10.1097/NEN.0b013e31827e5762 76 KoppenolW

doi: 10.1002/oby.22534

The suppression of autophagy, either through genetic approaches (e.g., knockout of autophagy-related genes like ATG5 ) or pharmacological inhibitors (e.g., chloroquine [CQ] or hydroxychloroquine [HCQ]), has been demonstrated to reduce tumor growth and to increase sensitivity to chemotherapy [112,113,114]

Immunovant anticipates sharing initial results from both of these clinical trials in the first half of 2026

While these alterations could represent some form of metabolic memory or epigenetic regulation due to altered DNA methylation [102, 103], this seems unlikely since genetic reprogramming of iPSCs is known to erase most epigenetic marks [104]

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