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doi: 10.1021/acs.bioconjchem.0c00302 79 ShiCWuJBPanD

Protein expression was induced with 1 mM isopropyl -D-1-thiogalactopyranoside (IPTG), and cells were incubated for 1 h to allow expression of the HaloTag protein

Elevated copper levels can also lead to a decrease in S-adenosylmethionine (SAMe) and glutathione levels, which can affect methylation and toxin removal from the body

This makes it a valuable therapy for managing symptoms and reducing flare-ups in inflammatory conditions

Our findings support the rationale of using blood DNA as a surrogate of brain tissue to analyze changes in CpG methylation level in patients with neurodegenerative diseases, opening the possibility for characterizing new biomarkers

For individuals where pigmentation has a metabolic or oxidative origin (rather than a purely superficial one), this makes a meaningful difference