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[DOI] [PubMed] [Google Scholar] 184.Mulak A, Tache Y, Larauche M

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Nrf2, a member of the capncollar family of basic regionleucine zipper transcription factors involved in transcription of antioxidant genes in response to xenobiotic stress, is also a critical regulator of cellular oxidative stress in sepsis (Kolls, 2006) and a regulator of exacerbated proinflammatory cytokine release (cytokine storm) and loss of T lymphocytes (leukopenia) that characterize the most aggressive presentation of SARS-CoV-2-mediated COVID-19 infection (Kobayashi et al., 2016

30 The paradox in this study and in others may be partially attributed to a response shift where aging adults experience a change in internal values