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"So we can't say they have cerebral folate deficiency," he says, "but we can say, okay there is some kind of block that would put them at risk." Another caveat is that leucovorin appears to help many children who do not have folate-blocking antibodies

If you have concerns about your B12 levels, talk with a registered dietitian or your healthcare provider, said Heather Greenlee, ND, PhD, MPH, an American Society of Clinical Oncology (ASCO) expert and medical director of the Integrative Medicine Program at Fred Hutch

BMC Medicine 2010;8:85