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In addition to their differentiation capabilities, a reduction in pro-inflammatory cytokines (IL-6, IL-8, TNF-) has been observed following the injection of MSCs, indicating that MSCs secrete immunomodulatory factors through paracrine effects to create a favorable microenvironment (Miguelez-Rivera et al., 2018)

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Cindrova-Davies T, Zhao X, Elder K, Jones CJP, Moffett A, Burton GJ, Turco MY (2021) Menstrual flow as a non-invasive source of endometrial organoids

Indeed, mTORC1 promotes Wnt-driven tumor initiation but limits colon cancer development upon chronic inflammation

This provides validation for the inclusion of glutathione synthetase, GshF, in the plasmid