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Discontinuation may be warranted if allergic reactions occur, if side effects persist despite slower dosing, or if baseline conditions (acute kidney injury, active infection) change

If it does not, the most defensible general approach is cold-chain handling: freezer storage for long-term dry powder, refrigerator storage for short-term reconstituted solution, and no casual room-temperature storage after mixing

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The residue was then homogenized in suspension with isolation buffer (10% w/v) using a hand-held glass homogenizer

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