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As the prodrugs had been tested as diastereomeric mixtures, further work in exploring which isomer(s) may be responsible for activity are ongoing

In vivo efficacy in airway disease models of N-(3, 5-dichloropyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyo xylic acid amide (AWD 12-281), a selective phosphodiesterase 4 inhibitor for inhaled administration

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