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As previously mentioned, high intakes of NAC in healthy individuals may have pro-oxidant effects [107109], and both oral [110] and systemically administered [83] NAC can be poorly tolerated

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Caspase-3 suppression: The "executioner" enzyme of apoptosis was reduced by 42.7%, directly blocking the cell death cascade

Besides being a potential source of more reactive free radicals via Fenton reaction, physiological generation of H 2 O 2 fulfills a second messenger role and can be transported across membranes by aquaporins, a family of proteins that act as peroxiporins (Sies, 2014)

Pernicious anaemia An autoimmune disease that develops when the body lacks the intrinsic factor necessary to naturally absorb vitamin B12 from food