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The 500 mg/day dose of curcumin used in the study falls well within the clinically safe range, as curcumin has been classified as Generally Recognized As Safe (GRAS) by the U.S

However, the specific contribution of metformin in the treatment of endometrial cancer remains unclear, and further research is needed to clarify its potential as an adjunct to existing cancer therapies

mTOR: its critical role in metabolic diseases, cancer, and the aging process

Reactive oxygen species (ROS)

The focus of current research on the role of NAC in bone metabolism regulation via innate immunity primarily centers on macrophage modulation, with fewer studies addressing its effects on neutrophils, mast cells and other innate immune cells (Figure 1C)

Antioxidants 12 , 501 (2023)