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anaphylactic reactions, although rare, have been reported following the injection of human immune globulin preparations.(20) Although no data are available, clinical experience with other immunoglobulin preparations suggests that the only manifestations would be pain and tenderness at the injection site

The compound's reputation rests on preclinical animal and in-vitro work, much of which is now compromised

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Nierenberg DW, Nordgren RE, Chang MB, et al