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Mechanisms underlying drug-induced ototoxicity The possible mechanisms by which ototoxic agents can influence auditory function are nerve demyelination, apoptosis via caspase cascade, glutamate toxicity, ROS overload, DNA/RNA damage, inhibition of mitochondrial protein synthesis, inner ear hypo-perfusion and ion disturbance on the background of gene mutations, and increased permeability of triggered drugs (Fig

[DOI] [PMC free article] [PubMed] [Google Scholar] 60.Ross CA, Tabrizi SJ

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Pharmacological features A complex of vitamins B is prescribed for inflammatory and degenerative diseases of the nerves and the motor apparatus, a deficiency of the group of vitamins B in the body

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