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The biggest problem is shrinkage of the brain cells

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Fortunately, end-expiratory breath alcohol concentration closely follows arterial blood alcohol concentration (see (100) as an example), leading to the use of the breathalyzer as a practical measure to predict brain alcohol concentration

Second, catecholamine levels and sympathetic nervous system activity are relatively elevated in the early morning, providing a favourable hormonal backdrop for beta-3 adrenergic activation

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Esposito G, Dottori L, Pivetta G, et al