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KRAS is an oncogenic protein that is commonly activated in many tumors, including lung cancer and pancreatic cancer, and it has been considered an undruggable target because it lacks a classical drug binding site 143,144

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In fact, a 2023 paper published in the Journal of Cerebral Blood Flow & Metabolism reported that methylene blue (in similar doses studied by researchers at The University of Texas at Austin who claimed the compound had memory-enhancing properties) led to a 8% decrease in human brain blood flow

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10.1089/ten.2006.0225 115

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