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Finally, the absence of validated biomarkers for predicting treatment response or monitoring efficacy further complicates both clinical research and practical application, limiting the ability to personalize therapy or objectively assess outcomes

Common mild side effects include injection-site irritation or temporary water retention, but serious reactions warrant immediate protocol adjustment or discontinuation

Together, these two mechanisms explain why low-dose atropine can paradoxically enhance vagal effects and slow sinoatrial node firing before higher doses shift the balance toward the expected anticholinergic tachycardia

doi: 10.1093/molehr/gat083

10.1016/j.plaphy.2006.06.002 38 Gomes-JuniorR