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This size range is critical: particles below 100 nm are cleared too rapidly by the renal system, while particles above 300 nm face significant physical barriers to intestinal absorption

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GSH is synthesized de novo in the brain by astrocytes and research has demonstrated increased GSH synthesis during oxidative stress-related toxicity in vitro , proposing in vivo synthesis of this antioxidant might be sufficient to not detect significant changes ( 4.2

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