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This buffer ratio varies with the pH, but owing to its relatively low concentration, it contributes little to the buffering capacity of the extracellular fluid

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Every aspect of the process from dose selection and escalation strategy to participant monitoring and safety review is designed to support informed decision-making while maintaining participant protection as the central priority

Attal M, Richardson PG, Rajkumar SV, et al

2002 Mar 1;108(2):140-7

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