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In our experience and from the information presented in this review, IGF-1 acts as the cornerstone maintaining homeostasis in this system

471 According to the PAKT trial, the addition of the AKT inhibitor capivasertib to the first-line paclitaxel therapy for TNBC resulted in significantly longer PFS and OS, especially in tumors with PIK3CA/AKT1/PTEN alterations

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Without maintenance sessions and daily protection, particularly with sunscreen, skin concerns such as dullness or pigmentation may gradually return over time

Many of these patients are prescribed immunosuppressant medications that place them at higher risk of complications

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