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Flubendazole, an antimalarial drug, inhibits SLC7A11/GPX4, promoting ferroptosis in castration-resistant prostate cancer (Zhou et al., 2021)

NBDHEX is an inhibitor for GSTs

Interestingly, HIF-1 transcription was found to be enhanced upon oxidative stress, resulting in an induction of different sets of HIF-1 target genes in pulmonary artery and vascular smooth muscle cells [79, 80]

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Gene Set Enrichment Analysis: A Knowledge-Based Approach for Interpreting Genome-Wide Expression Profiles

There is also further ongoing research to understand the mechanisms of GIP agonism versus antagonism to decide on the optimal weight loss and antihyperglycemic approach