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Effect of Metformin vs Placebo on Invasive DiseaseFree Survival in Patients With Breast Cancer: The MA.32 Randomized Clinical Trial

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Competing interests All authors declared the absence of any financial or personal conflicts pertaining to this work

Arsenic accumulation in the vacuole rose by 112% under stress, and phytohormones promoted vacuolar sequestration by up to 32%, while reducing cytosolic As by up to 23%, indicating improved detoxification via compartmentalization