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Science 123 , 309314 (1956)

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In addition, co-exposure to both bisphenols during the first trimester of pregnancy was significantly associated with neonatal TSH levels, and females might be more susceptible ( Thyroid volume was described to be increased with age after BPA exposure in 718 Chinese, 911 year-old children, and the incidence of multiple thyroid nodules also increased with age ( When considering phthalates, exposure to di-(2-ethylhexyl) phthalate (DEHP) metabolites in rats was mainly associated with altered pituitary TSH secretion and disrupted thyroid hormone homeostasis with changes in receptor expression levels ( in vivo studies have shown that the complex effects of DEHP and BPA mixtures may lead to reduced thyroid weight, which ultimately would affect the development of the thyroid gland ( The Columbia Center study showed that maternal urinary mono-(2-ethylhexyl) phthalate (MEHP) levels were positively linked with fT4 in children at age 3 years ( A large US study in 356 adolescents aged 1219 years showed a positive correlation between TT3 and TSH with mono(carboxyisoctyl) phthalate (MCOP) and a negative correlation of TSH with MCNP