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E: Superoxide dismutase (SOD) activity

Mutant -synuclein protein is also known to inhibit the expression and activity of catalase [123]

Through miR-429 , Rg3 regulates genes associated with apoptosis in gastric cancer (AGSR-CDPP) cells resistant to cisplatin [662], regulates cancer cell apoptosis via the MEK signaling pathway in melanoma (A375.S2) cells [663], and promotes p53 demethylation and histone acetylation of p21 and p16 to enhance apoptosis of renal cell carcinoma cells [664]

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This paper describes that treatment of human cancer cells having steroid hormone receptors with the appropriate hormone, oestrogen and/or progesterone, significantly increases the potency of cisplatin and its analogue carboplatin by causing the overexpression of HMGB1
