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Clinically, DFP, as an oral hydroxypyridone derivative, is used in the treatment of diseases such as Friedreich's ataxia and thalassemia (Aminzadeh-Gohari et al

EFS rate, 70%) and patients with undetectable disease (12-month OS rate, 95%

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In line with decreased expression of key enzymes involving -oxidation (Figure 3, A and B), metabolomic analysis demonstrated significantly decreased levels of multiple acyl-carnitine species, without alterations in free carnitine levels (Figure 4, EG)

We demonstrated that GSTM2 suppressed the progression of hepatic steatosis by inhibiting ASK1-p38/JNK signalling

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