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Botanical drugs and isolated metabolites have progressively become a burgeoning area of interest in anti-tumor drug research (Xing et al., 2023

This process is kinetically slow under biological conditions of neutral pH, due to the very low concentration of the free thiolate groups, which are the true active agents of the reaction, as depicted in Scheme 12

Furthermore, Seahorse experiments demonstrated that overexpression of AGXT in HepG2 cells treated with PA significantly enhanced basal respiration, maximal respiration and ATP production compared with GFP control (Fig

These effects collectively contribute to reproductive toxicity

Tesniere A, Schlemmer F, Boige V, Kepp O, Martins I, Ghiringhelli F et al