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To a lesser extent, CYP1A1 also participates in drug metabolism, thus co-administering CYP1A1 inducers can decrease bedaquiline concentrations neglecting its effectiveness

Not all patients experience these side effects, but in those who do, both will go away shortly

doi: 10.1212/con.0000000000000362

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In wild and mutant models, the average distance between the -carbon backbones is measured by RMSD, whereas topological similarity is assessed by TM-score