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Diacylglycerol and protein kinase C regulate a broad range of gene transcription programs but also modulate integrins, chemokine responses and antigen receptors, thereby regulating lymphocyte adhesion, migration, differentiation and proliferation.

The diagnosis of CIPN relies heavily on identifying symptoms, with limited objective diagnostic approaches targeting the class of affected nerve fibres

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Vitamin E strengthens the skin's immune system

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Congenital malformations:  A meta-analysis (including registries and cohort studies) showed that about 11% of children of epileptic women exposed to Divalproex sodium/valproate/valproic acid monotherapy during pregnancy had major congenital malformations