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In vitro treatment of TMAO together with pro-inflammatory cytokine TNF- can increase the proliferation (detected by the cell-counting Kit-8 assay), migration (detected by the wound healing assay and the transwell assay), and invasion [detected by the expression levels of periostin, integrin-linked kinase (ILK)/RAC- serine/threonine-protein kinase (AKT1), and the mammalian target of rapamycin (mTOR)] of mouse liver cancer cell line Hepa16 cells and human liver cancer cell line Huh7 cells [64]

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Recent studies have shown that underlying genetic abnormalities may identify a cohort of patients who would respond to OCA

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[DOI] [PMC free article] [PubMed] [Google Scholar] 91.Regulation (EU) No 1169/2011 of the European Parliament and of the Council of 25 October 2011 on the Provision of Food Information to Consumers, Amending Regulations (EC) No 1924/2006 and (EC) No 1925/2006 of the European Parliament and of the Council, and Repealing Commission Directive 87/250/EEC, Council Directive 90/496/EEC, Commission Directive 1999/10/EC, Directive 2000/13/EC of the European Parliament and of the Council, Commission Directives 2002/67/EC and 2008/5/EC and Commission Regulation (EC) No 608/2004 Text with EEA Relevance

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