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Briefly, six burr holes were drilled in three horizontal lines, all of them medial to the superior temporal lines and temporalis muscle attachments

The in vitro studies formed the foundation of the investigation

The safety data for each compound individually is reassuring, but combination safety requires its own evaluation because pharmacological interactions can produce unexpected results even when each agent is well-characterized on its own

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This rise in cAMP appears to activate protein kinase A (PKA), which then may lead to the phosphorylation of various proteins, including voltage-dependent calcium channels on the cell membrane