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Despite having an up-regulated basal antioxidant response, STIM1-deficient mouse embryonic fibroblasts experience an imbalance of ROS production and detoxification upon addition of exogenous oxidants (101)
Phase II study of fludarabine, cytarabine (Ara-C), cyclophosphamide, cisplatin and GM-CSF (FACPGM) in patients with Richter's syndrome or refractory lymphoproliferative disorders
2007;292:L56776
Thus, aloin and aloe-emodin possibly suppress inflammatory responses by blocking iNOS and COX-2 mRNA expression
In addition to triplet oxygen, singlet oxygen can also be formed in biological systems
