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Prior to the study of these targeted compounds, gastrointestinal inflammation research relied largely on broad anti-inflammatory agents and nonspecific interventions

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Although alterations in genetic factors have been linked with its etiology, exponential accumulation of environmental entities such as reactive oxygen species (ROS) initiate a cyclic chain reaction resulting in accumulation of cellular inclusions, dysfunctional mitochondria, and overwhelming of antioxidant machinery, thus accelerating disease pathogenesis

For B12 deficiency with neurological symptoms, administer hydroxocobalamin 1 mg intramuscularly on alternate days until no further improvement occurs, then t...

This review particularly emphasizes the roles of NR and GSNOR enzymes in NO homeostasis and NO-mediated plant responses to environmental challenges.