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10.1128/JVI.74.5.2293-2304.2000 Bartenschlager R, Ahlborn-Laake L, Mous J, Jacobsen H: Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions

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Therefore, it is possible that the expression of hsp-4p::gfp reporter is compromised in hsf-1 (RNAi) animals because decreased HSP-70 and/or HSP-90 protein levels result in IRE-1 destabilization

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Carnitine levels are normally less depleted in secondary carnitine deficiency when compared to OCTN2-deficient patients, and therefore smaller doses of L-carnitine can restore the carnitine levels in a shorter period of time than in patients with primary deficiency [41]