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Similarly, tobacco exposure also resulted in a significantly higher mRNA expression of PARP, a marker of DNA damage and indicator of apoptosis, 43, 44 suggesting that the more extensive MI in tobacco-exposed rats is also accompanied by an increase in cardiomyocyte apoptosis

doi:10.1001/jama.285.23.2981 [19] Bradlow HL, Michnovicz JJ, Halper M, Miller DG, Wong GY, Osborne MP

Clinically, in patients with heart failure, forskolin decreases ventricular filling pressures and vascular resistance while increasing cardiac output, ejection fraction, and stroke volume (Bristow et al., 1984)