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Following SCI, lesion-adjacent microglia phagocytose cellular debris and secrete pro-inflammatory cytokines that recruit infiltrating immune cells into the spinal cord (SC) (Hakim et al., 2021

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Nat Commun (2020) 11:1995

However, its mechanistic variability across models underscores the need for: (1) unified mechanistic studies, (2) advanced in vivo models, (3) early-phase clinical trials to evaluate human safety and efficacy

This suggests that the detection rate of LAM testing when combined with other diagnostic methods, may be superior to LAM testing alone

Kong, J., Crissey, M