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Description

This includes the use of advanced analytical techniques (e.g., liquid chromatography-mass spectrometry) to quantify TCM components and their metabolites in plasma, gut, and liver tissues, as well as the integration of pharmacokinetic and pharmacodynamic data to establish doseresponse relationships

A 15minute simple reaction task assessed motor function during and after stimulation

The outcomes showed that CLA administration resulted in lower IL-8 and carcinoembryonic antigen (CEA) levels compared to the control, as well as an increase in malondialdehyde (MDA), indicating lower oxidative stress

it inhibits microglial activation and has been shown to reduce serum levels of inflammatory cytokines in toxininduced parkinsonian rats [43, 44]

The frequency and risk factor of SCD were distinct in PD with and without MCI, which suggested that SCD in early PD with different cognitive status appears to have different pathogenicity (Pan et al., 2021)