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Depletion of this pool in brain mitochondria makes them more vulnerable to toxic effects of H 2 O 2 leading to irreversible damages [45] and death

[18] However, protein intake is proven to increase IGF1 levels

Cancer Cell 33 , 905921.e905 (2018)

In summary, glutathione acts as a critical determinant in regulating the inflammatory potential of infiltrating immune cells

All lysine methyltransferase enzymes belong to the large family of enzymes identified as the methyltransferase family

2.4 Correlation between GPX4 downregulation and OA severity Extensive clinical pathological analyses and rigorously controlled animal model studies collectively reveal a clear pattern: the protein expression level or biological activity of GPX4 typically shows a significant negative correlation with the severity of OA lesions