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Future efforts should prioritize systematic, mechanistic studies in wellphenotyped patient cohorts, the development of objective diagnostic tools to differentiate pain types, and rigorous clinical testing of novel interventions like CAP

Individuals with Digestive Issues Crohns disease, celiac disease, or gastritis Weight loss surgery patients Those taking acid-reducing medications 5

Expression of the Human Isoform of Glutamate Dehydrogenase, hGDH2, Augments TCA Cycle Capacity and Oxidative Metabolism of Glutamate During Glucose Deprivation in Astrocytes. Glia 65: 474488
Targeting of alphav integrin identifies a core molecular pathway that regulates fibrosis in several organs

Golgi stress response reprograms cysteine metabolism to confer Cytoprotection in Huntington's disease

doi: 10.1021/acschembio.5b00245