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As the upregulated cluster 1 genes resemble a proinflammatory signature characteristic for a senescence-associated secretory phenotype (SASP) [39], we examined the GNE/BMS-regulated secretome in KRAS G12V /MYC cells by Olink Explore primer extension assays (PEA) (Supplementary Fig

& Nothaft, W

Thiele J

Testosterones conversion to dihydrotestosterone further enhances this inhibitory effect, reducing CRH and AVP mRNA expression in the PVN, decreasing POMC mRNA in the pituitary, and enhancing GR-mediated feedback 83

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