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7 (2022): e0271770, 10.1371/journal.pone.0271770

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Cocoa Flavanols Improve Endothelial Functional Integrity in Healthy Young and Elderly Subjects

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During the early stages of APAP-induced liver injury, stressed and damaged hepatocytes release various endogenous DAMPs, such as HMGB1, 75 nuclear DNA fragments, 76 uric acid, 77 mitochondrial DNA, 76 ATP, and heat shock protein-70, an inducible stress response protein that is translocated to the cell surface and released during cellular stress or necrotic death