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However, the road we just started is long and still partially obscure and it is clear that the scientific adventure has just begun

Recently, a double blinded randomised controlled trial was published in which participants were administered either methyl-cobalamin or placebo for 6 weeks and then their treatment switched without washout for a further 6 weeks [64]

Serious reactions are extremely uncommon

JCI Insight 2(12):e93411

[DOI] [PMC free article] [PubMed] [Google Scholar] 224.Carthew R.W

Trial subjects reported improved skin hydration within 1-2 weeks, noticeable texture and firmness improvements at 4-8 weeks, and reduced fine lines with better skin resilience at 8-12+ weeks