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457 Disturbances in BCAA metabolism also play a critical role, with elevated BCAA levels detected in failing hearts, likely due to impaired BCAA oxidation during heart failure

344 Furthermore, lactylation is implicated in the progression of musculoskeletal diseases such as osteoarthritis (OA), intervertebral disc degeneration (IDD), and tendinopathy

This reactive hyperaemia causes brain damage through higher free radical production and neutrophil influx which has a special role in chronic inflammation (32, 34)

Materials and Methods The University of Floridas Institutional Review Board provided ethical approval for the study, and all participants provided their written informed consent at the first testing session

10.15252/embr.201949863 201 XuF.SuyamaR.InadaT.KawaguchiS.KaiT

Breeding of glutathione producing strain and study on shaking flask fermentation: M.C.E