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Participants were randomized 21:3:3:7 to CagriSema 2.4 mg/2.4 mg, semaglutide 2.4 mg, cagrilintide 2.4 mg, or placebo, and lifestyle intervention in all study groups for 68 weeks

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It should be noted, however, that some of the studies cited herein include analyses or investigations involving human participants, which were conducted and completed prior to the commencement of the present work

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In addition, a recent study also revealed that the liver-specific Ulk1 and Ulk2 double knockout mice, where Ulk1 and Ulk2 were key components of the unc-51-like autophagy activating kinase 1 (ULK1) complex that functions upstream of the autophagy pathway, were more resistant to APAP-induced liver injury

This suggests the need for optimized delivery methods