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While short-term fasting decreases serum IGF-I but does not affect GHBP (69), the triad of IGF-I deficiency, poor growth and pubertal delay/arrest in long term nutritional deficiency such as in anorexia nervosa is associated with low GHBP that is partly restored with weight gain (63)

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This highlights the need for investigation of the structure of CCK1R and CCK2R to understand agonist binding, receptor activation and thus promote structure-based drug discovery

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