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Evidence suggests that abnormal lipid metabolism is frequently observed in autoimmune diseases, underscoring its potential involvement in disease development

Kroon, E

Studies have shown that alcohol causes an overexpression of the CYP2E1 enzyme, and inhibition of this enzyme significantly reduces liver damage caused by alcohol

Immunosenescence contributes to: At the same time , many older adults experience "inflammaging," a state of persistent low-grade inflammation that accelerates biological aging

The combination of AGEs and RAGEs, PKC activation, polyol pathway and Ang-II can stimulate ROS production and induce oxidative stress (Tanase et al., 2022)

Under hypoxic conditions, hydroxylase is inactivated, leading to the accumulation of HIF-1 and EGLN and the induction of survival gene transcription to adapt to the hypoxic environment