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Li Y, Teng D, Ba J, Chen B, Du J, He L et al (2020) Efficacy and Safety of Long-Term Universal Salt Iodization on Thyroid Disorders: Epidemiological Evidence from 31 Provinces of Mainland China

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Pain Processing Mechanisms Central Sensitization (via mGlu2 receptor upregulation)[4][5] Neuroinflammation (modulates glial activation)[12][13] Mitochondrial Dysfunction (enhances ATP production, -oxidation)[2][13] Oxidative Stress (direct antioxidant activity)[2][13] Systemic Inflammation limited direct evidence SUMMARY OVERVIEW CLINICAL PEARLS 1

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To date it has been impossible to predict the duration of the initial response and remission under ADT and, thus, to adjust treatment plans based on CaP tissue or circulating tumor cell characteristics to maximize such responses