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In contrast, NADPH oxidase and p53 (especially acetylation-defective mutant p53) act as positive regulators of ferroptosis by promotion of ROS production and inhibition of expression of SLC7A11 (a specific light-chain subunit of the cystine/glutamate antiporter), respectively
doi: 10.1172/JCI41062
(2019) 30:86576.e5
In addition, cytoskeletal proteins and other cellular proteins are damaged by an overabundance of free radicals in the intestinal epithelium
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